师资队伍
齐月恒,博士/副教授,三峡大学硕士生导师,中共党员,现任洛阳师范学院食品与药品学院制药工程系党支部书记、系副主任。2021年获得北京师范大学理学博士学位。近年来在Mol. Pharm、J. Org. Chem.、Front. Microbiol.、Molecules、ACS Omega、Front. Chem.、Spectroc. Acta Pt. A-Molec. Biomolec. Spectr、ACS Appl. Mater. Interfaces 等期刊发表SCI文章10余篇,授权发明专利4项,主持省部级课题1项。
联系方式:qiyueheng@lynu.edu.cn
研究领域和兴趣:
1. 计算机辅助药物设计
2. 靶向抗肿瘤药物的设计、合成及生物评价研究
3. 荧光探针的设计、合成及应用
教育经历:
2009.09-2013.07 河南工业大学 生物技术专业 学士
2013.09-2016.07 河南工业大学 有机化学专业 硕士
2016.09-2021.01 北京师范大学大学 药物化学与分子工程专业 博士
工作背景:
2021.03-2025.12 洛阳师范学院食品与药品学院,讲师
2026.01-至今 洛阳师范学院食品与药品学院,副教授
主持科研项目:
1.河南省科技厅科技攻关项目(222102310356):新型靶向IspH双效免疫抗菌药的设计、合成及药效研究,2022.01-2023.12,主持。
2.河南省高等学校重点科研项目(22B350004):新型靶向RORγt抑制剂的设计、合成及抗肥胖药效研究,2022.01-2024.12,主持。
发表代表性论文:
1.Y. Qi, B. Xue, S. Chen, W. Wang, H. Zhou, H. Chen, Synthesis, biological evaluation, and molecular docking of novel hydroxyzine derivatives as potential AR antagonists, Front. Chem. 10 (2022), 1053675.
2.Y. Qi, H. Chen, S. Chen, J. Shen, J. Li, Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists, Front. Chem. 10 (2022), 947065.
3.Y. Qi, H. Xu, H. Chen, Recent Progress in Silver-Ion-Selective Fluorescence Chemical Sensors, ACS Omega 10 (2025), 11743-11754.
4.Y. Qi, P. Ji, K. Yin, Y. Zheng, J. Niu, A. Jia, J. Zhou, J. Li, Phloretin Inhibits Quorum Sensing and Biofilm Formation in Serratia marcescens, Molecules 28 (2023).
5.Y. Qi, Y. Li, Y. Fang, H. Gao, B. Qiang, S. Wang, H. Zhang, Design, Synthesis, Biological Evaluation, and Molecular Docking of 2,4-Diaminopyrimidine Derivatives Targeting Focal Adhesion Kinase as Tumor Radiotracers, Mol. Pharm. 18 (2021), 1634-1642.
6.Y. Qi, Y. Li, Y. Fang, B. Qiang, H. Gao, S. Wang, H. Zhang, Design, synthesis, and biological evaluation of F-18-labelled 2, 4-diaminopyrimidine-type FAK-targeted inhibitors as potential tumour imaging agents, Bioorg. Med. Chem. Lett. 30 (2020), 127452.
7.H. Xu, Y. Han, Y. Zhu, L. Chen, J. Xu, Z. Shan, H. Chen, Y. Qi*, Z. Guo, Bifunctional phenothiazine-Coumarin probe Tz.3: Visual detection of Ag(+)/ ClO(-) in aqueous media and selective imaging of hypochlorite in living cells, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 344 (2026), 126730.
8.H. Zhang, Y. Qi, X. Zhao, M. Li, R. Wang, H. Cheng, Z. Li, H. Guo, Z. Li, Dithienylethene-Bridged Fluoroquinolone Derivatives for Imaging-Guided Reversible Control of Antibacterial Activity, J. Org. Chem. 87 (2022), 7446-7455.
9.Y. Li, Y. Qi, Y. Fang, H. Gao, H. Zhang, Design, Synthesis, and Biological Evaluation of 4-Arylamino Pyrimidine Derivatives as FAK Inhibitors and Tumor Radiotracers, Mol. Pharm. 19 (2022), 2471-2482.
10.H. Chen, J. Luo, S. Chen, Y. Qi, T. Zhou, X. Tian, F. Ding, Sensing Hypochlorite or pH variations in live cells and zebrafish with a novel dual-functional ratiometric and colorimetric chemosensor, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 271 (2022), 120915.
发明专利:
1.专利:一种用于检测Cu2+、BPO的比色荧光探针TZ6及其制备方法和应用。齐月恒;徐华鑫;陈洪;陈豪威;庞舒云;常怡柯;向锶雨。授权公告号:CN 119462693 B。专 利 号:ZL 2025 1 0063640.5。
2.专利:一种基于吩噻嗪检测Ag+和ClO-的荧光探针Tz3及其制备方法和应用。齐月恒;徐华鑫;陈洪;卓瞻;李雨杰;张祎楠;吕延瑞;徐建业;单志豪。授权公告号:CN 119504794 B。专 利 号:ZL 2025 1 0074969.1。