李自永，博士/副教授，1983年2月生，河南滑县人，中共党员，三峡大学兼职硕士生导师，洛阳师范学院“双师双能型”教师。指导的学生获得2019年度河南省大学生挑战杯二等奖。近年来，在Chem. Commun., Org. Lett., J. Org. Chem., Org. Biomol. Chem., Dyes Pigments, Eur. J. Org. Chem.等国际权威期刊发表SCI论文40余篇，其中第一作者或通讯作者SCI论文30篇。

联系方式：liziyong@mails.ccnu.edu.cn 

研究领域和兴趣：

1.        光开关型抗菌剂设计、合成、抑菌活性及抗细菌耐药性研究；

2.        长波长可见光控制的近红外二噻吩乙烯光致变色材料的开发及在生物体系中的应用；

3.        光致变色传感膜的开发及在食品或环境污染物检测中的应用；

4.        新药或仿制药合成工艺开发；

教育经历：

2004.09-2008.06 许昌学院       应用化学专业      学士

2008.09-2014.06 华中师范大学   有机化学专业      博士

工作背景：

2014.06-2016.06   武汉药明康德新药开发有限公司，项目负责人

2016.06-2019.12   洛阳师范学院食品与药品学院，讲师

2020.01-至今　    洛阳师范学院食品与药品学院，副教授

主持科研项目：

1.        河南省高等学校重点科研项目（18A150012），基于二噻吩乙烯结构单元开关型抗菌药物的设计、合成及性能研究，2018.01 -2019.12，5万元，主持。

2.        洛阳师范学院国家级项目培育基金（2017-PYJJ-005），基于二噻吩乙烯单元红光/近红外开关型抗菌剂的设计、合成及性能研究，2018. 01-2020.12，5万元，主持。

发表代表性论文：

1.         Ziyong Li*, Yijie Dai, Zhiqiang Lu*, Yingying Pei, Hong Chen, Lilei Zhang, Ying Duan and Hui Guo*, Efficient green light-excited switches based on dithienylethenes with BF₂-doped p-conjugated systems. Chemical Communications, 2019, 55, 13430-13433.

2.         Ziyong Li*, Yingying Pei, Yangyang Wang, Zhiqiang Lu, Yijie Dai, Ying Duan, Yongjie Ma and Hui Guo*, Blue-/NIR Light-Excited Fluorescence Switch Based on a Carbazole- Dithienylethene-BF₂bdk Triad. Journal of Organic Chemistry, 2019, 84, 13364-13373.

3.         Ziyong Li*, Yingying Pei, Siteng Hou, Yijie Dai, Duoduo Liu, Junli Zhu, Yan-Ping Zhu*,  Xianming Liu*, Dithienylethene-bridged difluoroboron β-diketonate dyes: Optical switching behaviors and triple sensing for volatile amine vapors. Dyes and Pigments, 2020, 179, 108419.

4.         Ziyong Li*, Yufei Song , Zhiqiang Lu, Zixu Li, Rong Li, Yunshuang Li, Siteng Hou, Yan-Ping Zhu*, Hui Guo*, Novel difluoroboron complexes of curcumin analogues as “dual-dual” sensing materials for volatile acid and amine vapors. Dyes and Pigments, 2020, 179, 108406.

5.         Ziyong Li*, Yangyang Wang, Mengna Li, Hong Chen, Yanfu Xie, Pengshou Li, Hui Guo* and Huiyuan Ya*, Solvent-dependent and visible light-activated NIR photochromic dithienylethene modified by difluoroboron β-diketonates as fluorescent turn-on pH sensor. Dyes and Pigments, 2019, 162, 339-347.

6.         Ziyong Li*, Mengna Li, Guoxing Liu, Yangyang Wang, Guohui Kang, Chaoyang Li and Hui Guo*, Synthesis, photophysical properties and NIR photochromism of photoresponsive difluoroboron β-diketonate complex based on dithienylethene unit. Dyes and Pigments, 2019, 160, 597-603.

7.         Ziyong Li*, Xuehui Li, Hong Chen, Chaojun He, Liye Wang, Yumin Yang, Sujun Wang, Hui Guo* and Sheng Hua Liu*, Multi-modulated Photochromic Behavior of a D-A Type Dithienylethene. Dyes and Pigments, 2019, 162, 712-720.

8.         Ziyong Li*, Yijie Dai, Zhiqiang Lu*, Yingying Pei, Yufei Song, Lilei Zhang and Hui Guo*, A Photoswitchable Triple Chemosensor for Cyanide Anion Based on Dicyanovinyl -Functionalized Dithienylethene. European Journal of Organic Chemistry, 2019, 3614-3621.

9.         Ziyong Li*, Yangyang Wang, Mengna Li, Haining Zhang, Hui Guo, Huiyuan Ya* and Jun Yin*, Synthesis and properties of dithienylethenefunctionalized switchable antibacterial agents. Organic & Biomolecular Chemistry, 2018, 16, 6988-6997.

10.     Ziyong Li*, Chaojun He, Yanbo Li, Yangyang Wang, Cangcang Wei, Jun Yin, Sheng Hua Liu, Construction and optical properties of dithienylethene-based photoswitchable [n]rotaxane (n = 2, 3). Dyes and Pigments, 2018, 148, 130-136.

11.     Ziyong Li #, Xie Han #, Haiyan Chen*, Di Wu, Fang Hu, Sheng Hua Liu* and Jun Yin*, Construction of photoswitchable rotaxanes and catenanes containing dithienylethene fragments. Organic & Biomolecular Chemistry, 2015, 13, 7313-7322.

12.     Ziyong Li, Fang Hu, Guoxing Liu, Wen Xue, Xiaoqiang Chen, Sheng Hua Liu* and Jun Yin*, Photo-responsive [2]catenanes: synthesis and properties. Organic & Biomolecular Chemistry, 2014, 12, 7702-7711. (Cover paper)

13.     Ziyong Li, Guoxing Liu, Wen Xue, Di Wu, Ying-Wei Yang, Jishan Wu, Sheng Hua Liu*, Juyoung Yoon* and Jun Yin*, Construction of Hetero[n]rotaxanes by Use of Polyfunctional Rotaxane Frameworks. Journal of Organic Chemistry, 2013, 78, 11560-11570.

14.     Ziyong Li, Wenju Liu, Jishan Wu, Sheng Hua Liu, and Jun Yin*, Synthesis of [2]Catenanes by Template-Directed Clipping Approach. Journal of Organic Chemistry, 2012, 77, 7129-7135.

15.     Ziyong Li, Chan Zhang, Yanliang Ren, Jun Yin* and Sheng Hua Liu*, Amide- and Urea-Functionalized Dithienylethene: Synthesis, Photochromism, and Binding with Halide Anions. Organic Letters, 2011, 13, 6022-6025.