陈洪，博士/副教授，三峡大学硕士生导师，中共党员，现任洛阳师范学院食品与药品学院副院长、洛阳市有机功能分子重点实验室主任。2012年获得中山大学理学博士学位，2012.07-2012.12在康龙化成（北京）新药技术有限公司从事科研工作，任课题组长。2013.01-2014.12在广州医科大学药学院从事博士后研究工作。2018.06-2021.07在南方医科大学南方医院从事博士后研究工作。Frontiers in Chemistry副主编，Talanta，Dyes and Pigments审稿人。近年来在ACS Applied Materials & Interfaces、Journal of Hazardous Materials、Journal of Agricultural and Food Chemistry、Inorganic chemistry、Sensors and Actuators B: Chemical、Chinese Chemical Letters、Analytica Chimica Acta、Talanta、Frontiers in Microbiology、Dyes and Pigments、Bioorganic & Medicinal Chemistry、Bioorganic & Medicinal Chemistry Letters等期刊发表SCI文章35余篇，授权发明专利4项，主持省部级课题6项。指导、培养硕士研究生6名。

联系方式：chenwexpo@sina.com

研究领域和兴趣：

1．靶向抗肿瘤药物的设计、合成及作用机制研究

2．活性天然产物的提取、分离，合成，结构修饰和构效关系研究

3. 小分子荧光探针的设计、合成及应用

教育经历：

2004.09-2006.07 河南师范大学   化学专业  学士

2006.09-2009.07 华南师范大学   有机化学专业  硕士

2009.09-2012.06 中山大学    有机化学专业  博士

工作背景：

2012.7-2012.12   康龙化成（北京）新药技术有限公司，课题组长

2013.01-2014.12   广州医科大学药物研究中心，药物化学 博士后  

2015.02-2018.11   洛阳师范学院食品与药品学院，讲师

2018.06-2021.07   南方医科大学南方医院，药物化学 博士后  

2018.12-至今　   洛阳师范学院食品与药品学院，副教授

主持科研项目：

1. 中国第54批博士后基金（2013M542165）：基于α1A/1D-AR靶点的拮抗剂的设计、合成与构效关系研究，2013.01-2015.01，5万，主持。

2．广东省自然科学基金（S2013040014088）：基于α1A/1D-AR靶点的拮抗剂的设计、合成与构效关系研究，2013.10-2015.10，3万，主持。

3. 2016年河南省科技攻关（社会发展）项目（162102310477），芳基哌嗪类衍生物的合成、生物活性及调控雄激素受体（AR）的研究，2016.01-2017.12，10万元，主持。

4. 2016年度河南省高等学校重点科研项目（16A350008），酰胺类芳基哌嗪衍生物的设计、合成及构效关系研究，2016.01-2017.12，3万元，主持。

5. 洛阳师范学院国家级项目培育基金（2015-PYJJ-005）：酰胺类芳基哌嗪衍生物的设计、合成及构效关系研究，2016.01-2018.12，5万元，主持。

6. 洛阳市有机功能分子重点实验室，2017，10万元，负责人。

7. 2021年度河南省高等学校重点科研项目（21A350006），抗耐药性AR拮抗剂的设计、合成及活性评价，2021.01-2022.12，3万元，主持。

8. 2021年河南省科技攻关（社会发展）项目（212102110241），基于新型聚集诱导发光材料的农药残留传感检测研究，2021.01-2022.12，主持。

9. 横向项目：天然产物bostrycin的全合成及活性评价（RH2100009223），2021.10-2023.10，25万元，主持。

发表代表性论文：

1. Hong Chen, Peng-Cheng Ji, Yue-Heng Qi, Shi-Jin Chen, Chang-Yao Wang, Yu- Jie Yang, Xin-Yu Zhao and Jin-Wei Zhou. Inactivation of Pseudomonas aeruginosa biofilms by thymoquinone in combination with nisin. Frontiers in Microbiology, 2023, 13, 1029412.

2. Hong Chen, Xiaoying Guan, Qianqian Liu, Longcui Yang, Jun Guo, Feng Gao, Yueheng Qi, Xiongting Wu, Feng Zhang, Xiumei Tian. Co-assembled nanocarriers of de novo thiol-activated hydrogen sulfide donors with an RGDFF pentapeptide for targeted therapy of non-small cell lung cancer. ACS Applied Materials & Interfaces, 2022, 14(48), 53475-53490.

3. Hong Chen, Jiamin Luo, Shijin Chen, Yueheng Qi, Tong Zhou, Xiumei Tian, Feng Ding. Sensing Hypochlorite or pH variations in live cells and zebrafish with a novel dual-functional ratiometric and colorimetric chemosensor. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2022, 271(4), 120915.

4. Yueheng Qi, baoli Xue, Shijin Chen, Wang Wang Haifeng Zhou* Hong Chen*. Synthesis, biological evaluation and molecular docking of novel hydroxyzine derivatives as potential AR antagonists. Frontiers in Chemistry, 2022, 10, 1053675.

5. Hong Chen, Qianqian Liu, Jiamin Luo, Yiliang Zhang, Zixia Liang, Yuanyuan Yang, Ziyong Li*, Shanchao Zhao*, Xiumei Tian*. Donor-acceptor type NIR dithienylethene with aggregation-induced emission for multi-state photochromic behavior. Dyes and Pigments. 2022, 199(3), 110055.

6. Yueheng Qi, Hong Chen*, Shijin Chen, Jianliang Shen* Jingguo Li*. Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists. Frontiers in Chemistry, 2022, 10, 947065。

7. Yanlei Wang, Feng Ding Xiaoshuai Sun, Shijin Chen, Huarong Huang*, Hong Chen*. A reaction-based colorimetric and ratiometric chemosensor for imaging identification of HClO in live cells, mung bean sprouts, and paper strips. Talanta. 2021, 234 (11), 122655.

8. Hong Chen, Zhan Zhou, Ziyong Li, Xiaojun He, Jianliang Shen. Highly sensitive fluorescent sensor based on coumarin organic dye for pyrophosphate ion turn-on biosensing in synovial fluid. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021, 257 (8), 119792.

9. Xiaojun He, Feng Ding, Xiaoshuai Sun, Yujing Zheng, Wei Xu, Lisong Ye, Hong Chen*, Jianliang Shen*. Renovated Multifunctional Colorimetric/Fluorometric Sensor for Simultaneous Detection, Imaging of pH Variance and Antimicrobial Therapies. Sensor. Actuat. B-Chem. 2021, 332, 129496.

10. Xiaojun He, Feng Ding, Xiaoshuai Sun, Yujing Zheng, Wei Xu, Lisong Ye, Hong Chen*, Jianliang Shen*. Reversible Chemosensor for Bioimaging and Biosensing of Zn(II) and hpH in Cells, Larval Zebrafish, and Plants with Dual-Channel Fluorescence Signals. Inorganic Chemistry 2021, 60(8), 5563-5572.

11. Xiaojun He, Zaian Deng, Wei Xu, Yahui Li, Chuchu Xu, Hong Chen*, Jianliang Shen*. A novel dual-response chemosensor for bioimaging of Exogenous/Endogenous hypochlorite and hydrazine in living cells, Pseudomonas aeruginosa and zebrafish. Sensor. Actuat. B-Chem. 2020, 321, 128450.

12. Xiaojun He, Wei Xu, Feng Ding, Chuchu Xu, Yahui Li, Hong Chen*, and Jianliang Shen*. A Reaction-Based Ratiometric and Colorimetric Chemosensor for Bioimaging of Biosulfite in Live Cells, Zebrafish and Food Samples. J. Agric. Food. Chem. 2020, 68(42), 11774–11781.

13. Hong Chen, Feng Ding, Zhan Zhou, Xiaojun He Jianliang Shen. FRET-based sensor for visualizing pH variation with colorimetric/ratiometric strategy and application for bioimaging in living cells, bacteria and zebrafish. Analyst 2020, 145(12), 4283–4294.

14. Xiaojun He, Feng Ding, Wei Xu, Chuchu Xu, Yahui Li, Yuna Qian, Shengzhe Zhao, Hong Chen*, Jianliang Shen. FRET-based colorimetric and ratiometric sensor for visualizing pH change and application for bioimaging in living cells, bacteria and zebrafish. Analytica Chimica Acta. 2020, 1127, 29-38.

15. Xiaojun He, Wei Xu, Chuchu Xu, Feng Ding, Hong Chen*, Jianliang Shen*. Reversible spiropyran-based chemosensor with pH-switches and application for bioimaging in living cells, Pseudomonas aeruginosa and zebrafish. Dyes Pigments. 2020, 180(9), 108497.

16. Hong Chen, Yuna Qian,·Huixia Jia, Yuzhong Yu, Haibo Zhang, Jianliang Shen*， Shanchao Zhao*. Synthesis and pharmacological evaluation of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety. Pharmacol Rep. 2020, 72(4), 1058–1068

17. Hong Chen, Xiaojun He, Yuzhong Yu, Yuna Qian, Jianliang Shen, Shanchao Zhao. Execution of aggregation-induced emission as nano-sensors for hypochlorite detection and application for bioimaging in living cells and zebrafish. Talanta 2020, 214(7), 120842.

18. Xiaojun He, Qi Xie, Jinyi Fan, Chuchu Xu, Wei Xu, Yahui Li, Feng Ding, Hui Deng*, Hong Chen*, Jianliang Shen*. Dual-functional chemosensor with colorimetric/ratiometric response to Cu(II)/Zn(II) ions and its applications in bioimaging and molecular logic gates. Dyes Pigments 2020, 177, 108255.

19. Xiaojun He, Chu-Chu Xu, Wei Xiong, Yu-Na Qian, Jin-Yi Fan, Feng Ding, Hui Deng, Hong Chen*, Jian-Liang Shen. The ICT-based fluorescence and colorimetric dual sensing of endogenous hypochlorite in living cells, bacteria, and zebrafish. Analyst 2020, 145, 29–33.

20. Xiaojun He, Hong Chen (并列第一), Chuchu Xu, Jinyi Fan, Wei Xu, Yahui Li, Hui Deng, Jianliang Shen. Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish. J. Hazard. Mater. 2020, 388(4), 122029. （高被引论文）

21. Hong Chen, PingYang, Ya-Hui Li, Li-Lei Zhang, Feng Ding, Xiao-Jun He, Jian-Liang Shen*. Insight into triphenylamine and coumarin serving as copper (II) sensorswith“OFF”strategy and for bio-imaging in living cells. Spectrochim. Acta A. 2020, 224, 117384.（高被引论文）

22. Hong Chen, Jing-Xiao Zhang, Pei-Xin Hu, Yu-Na Qian, Jing Li, Jian-Liang Shen. Synthesis, biological evaluation and molecular docking of 4-Amino-2Hbenzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety. Bioorg. Med. Chem. 2019, 27(20), 115081.

23. Hong Chen, Yu-Zhong Yu, Xiu-Mei Tian, Cai-Lu Wang, Yu-Na Qian, Zai-An Deng, Jing-Xiao Zhang, Dao-Jun Lv, Hai-Bo Zhang, Jian-Liang Shen*, Mu Yuan*, Shan-Chao Zhao. Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents. Bioorg. Med. Chem. 2019, 27(1), 133–143.

24. Xiao-Jun He, Cheng-Lin Wu, Yu-Na Qian, Li-Lei Zhang, Feng Ding, Hong Chen*, Jian-Liang Shen. Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo. Analyst 2019, 144, 3807–3816.

25. Hong Chen, Tao Sun, Xiao-Guang Qiao, Qian-Oian Tang, Shan-Chao Zhao*, Zhan Zhou*. Red-emitting fluorescent probe for detecting hypochlorite acid in vitro and in vivo. Spectrochim. Acta A. 2018, 204, 196–202.

26. Hong Chen, Zong-Lin Yang, Tao Sun, Jiang-Xiu Niu, Xiu-Mei Tian*, Mu Yuan*. Synthesis and Biological Evaluation of Arylpiperazine Derivatives as Anticancer Agents. Lett. Org. Chem. 2018, 15, 981–989.

27. Hong Chen, Xue Liang, Tao Sun, Xiao-Guang Qiao, Zhan Zhou, Zi-Yong Li, Chao-Jun He, Hui-Yuan Ya*, Mu Yuan*. Synthesis and biological evaluation of estrone 3-O-ether derivatives containing the piperazine moiety. Steroids 2018, 134, 101–109.

28. Hong Chen, Cai-Lu Wang, Tao Sun, Zhan Zhou, Jiang-Xiu Niu, Xiu-Mei Tian*, Mu Yuan*. Synthesis, Biological Evaluation and SAR of Naftopidil-based Arylpiperazine Derivatives. Bioorg. Med. Chem. Lett. 2018, 28, 1534–1539.

29. Hong Chen, Bing-Bing Xu, Tao Sun, Zhan Zhou, Hui-Yuan Ya*, Mu Yuan*. Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety. Molecules 2017, 22, 1857.

30. Hong Chen, Fang Xu, Bing-Bing Xu, Jing-Yi Xu, Bin-Hao Shao, Bi-Yun Huang, Mu Yuan*. Design, synthesis and biological evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines. Chinese Chem. Lett. 2016, 27, 277–282.

31. Hong Chen, Fang Xu, Xue Liang, Bing-Bing Xu, Zong-Lin Yang, Xue-Lan He, Bi-Yun Huang, Mu Yuan *. Design, Synthesis and Biological Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines. Bioorg. Med. Chem. Lett. 2015, 25, 285-287.

32. Hong Chen, Xue Liang, Fang Xu, Bing-Bing Xu, Xue-Lan He, Bi-Yun Huang, Mu Yuan *. Synthesis of novel arylpiperazine derivatives and their cytotoxic activity. Molecules 2014, 19, 12048-12064.

33. Hong Chen, Xun Zhu, Li-Li Zhong, Bing Yang, Jia Li, Jue-Heng Wu, Sheng-Ping Chen, Yu-Hua Long, Zhi-Gang She*. Synthesis and antitumor activities of derivatives of the marine mangrove fungal metabolite deoxyBostrycin. Marine Drugs 2012, 10, 2715-2728.

34. Hong Chen, Li-Li Zhong, Yu-Hua Long, Jia Li, Jue-Heng Wu, Lan Liu, Sheng-Ping Chen, Meng-Feng Li, Yong-Cheng Lin, Xun Zhu, Zhi-Gang She*. Studies on the Synthesis of Derivatives of Marine-derived Bostrycin and Their Structure-activity Relationship against Tumor cells. Marine Drugs 2012, 10, 932-952.

发明专利：

1. 陈洪，马录芳，姚景才，冯爱青，孙涛，罗光远，王豹，陈夏雨，俞佳俊。醚类芳基哌嗪衍生物及其盐、制备方法和用途，授权号：ZL 2015 10561570.2。

2. 陈洪，孙涛，周战，押辉远，冯爱青，许启泰。羟嗪衍生物以及制备方法，用途和制剂，授权号：ZL 2016 1 0986650.5。

3. 陈洪，王利亚，汪彩露，孙涛，孙献仲，李自永，许启泰。 醚类芳基哌嗪衍生物及其盐、制备方法以及用于制备治疗抗肿瘤药物的用途，授权号：ZL 2017 1 0145374.6。

4. 陈洪，周战，薛宝丽，齐月恒，王望，柏自松。聚集诱导发光光敏剂及其合成方法和应用，申请号：202310359455.1。

获奖情况：

1. 陈洪，Design, synthesis and biological evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines, Chinese Chem. Lett. 2016, 27, 277–282, 河南省第四届自然科学学术三等奖，2018年。

2. 第四届广东医学科技奖，一等奖，中国人前列腺癌的分子特征及精准诊疗的关键技术研究（R5），2022年。

3. 2022年中华医学科技奖，二等奖，中国人前列腺癌发生发展的分子机制特点及精准防洽的关键技术研究（R5），2022年。